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ea0029p824 | Endocrine tumours and neoplasia | ICEECE2012

Effects of mitotane on gene expression in the NCI-H295R cell line

Zsippai A. , Szabo D. , Tombol Z. , Szabo P. , Eder K. , Patocs A. , Toth S. , Falus A. , Racz K. , Igaz P.

Background: The adrenolytic agent mitotane is widely used in the adjuvant treatment of adrenocortical cancer, but its mechanism of action including potential effects on mRNA expression is poorly elucidated.Objective: To examine mitotane-induced mRNA expression changes in the H295R adrenocortical cancer cell line.Methods: Various concentrations of mitotane in different treatment periods (24–120 h) have been tested in cell viabi...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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